ABI1 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-15453
宿主: Rabbit
反应性: H,M,R
应用: WB,IHC
Overview
| Synonyms | Abelson interactor 1,Abi-1,Abi1,ABI1,Abl binding protein 4,Abl interactor 1,Abl interactor protein 1,Abl-binding protein 4,AblBP4,e3B1,Eps8 binding protein,Eps8 SH3 domain binding protein,Eps8 SH3 domain-binding protein,Eps8-binding protein,Hssh3bp1,Interactor protein AblBP4,NAP1,Nap1 binding protein,Nap1-binding protein,Nap1BP,Spectrin SH3 domain binding protein 1,Spectrin SH3 domain-binding protein 1,SSH3BP,ABI1抗体 |
| Swissprot | Q8IZP0 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Synthetic peptide of human ABI1 |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213) |
| Recommended dilution | WB,,1:500-1:2000;IHC,,1:50-1:200; |
| Concentration | 0.6 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm. Nucleus. Cell projection>lamellipodium. Cell projection>filopodium. Cell projection>growth cone. Cell junction>synapse>synaptosome. Cytoplasm>cytoskeleton. Localized to protruding lamellipodia and filopodia tips. Also localized to neuronal growth cones and synaptosomes. |
| Tissue specificity | Widely expressed, with highest expression in brain. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | This gene encodes a member of the Abelson-interactor family of adaptor proteins. These proteins facilitate signal transduction as components of several multiprotein complexes, and regulate actin polymerization and cytoskeletal remodeling through interactions with Abelson tyrosine kinases. The encoded protein plays a role in macropinocytosis as a component of the WAVE2 complex, and also forms a complex with EPS8 and SOS1 that mediates signal transduction from Ras to Rac. This gene may play a role in the progression of several malignancies including melanoma, colon cancer and breast cancer, and a t(10;11) chromosomal translocation involving this gene and the MLL gene has been associated with acute myeloid leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 14 |
Images
Western Blot analysis of Human fetal brain tissue using ABI1 Polyclonal Antibody at dilution of 1:300
Immunohistochemistry of paraffin-embedded Human cervical cancer using ABI1 Polyclonal Antibody at dilution of 1:40
Immunohistochemistry of paraffin-embedded Human gastric cancer using ABI1 Polyclonal Antibody at dilution of 1:40
