ABI2 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-18253
宿主: Rabbit
反应性: H
应用: IHC
Overview
| Synonyms | Abelson interactor 2,ABI 2,Abi-2,ABI2,ABI2,ABI2B,Abl binding protein 3,Abl interacting protein 1 (SH3 containing protein),Abl interactor 2,Abl interactor protein 2b,Abl-binding protein 3,AblBP3,AIP 1,Arg binding protein 1,Arg protein tyrosine kinase binding protein,Arg-binding protein 1,ArgBP1,ARGBPIA,ArgBPIB,OTTHUMP00000163783,OTTHUMP00000163784,OTTHUMP00000206182,OTTHUMP00000206183,OTTHUMP00000206184,OTTHUMP00000206185,SSH3BP2,ABI2抗体 |
| Swissprot | Q9NYB9 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Fusion protein of human ABI2 |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:50-1:100 |
| Concentration | 0.78mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm and Cell projection>lamellipodium. Cell projection>filopodium. Cytoplasm>cytoskeleton. Isoform 1 but not isoform 3 is localized to protruding lamellipodia and filopodia tips. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | May act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes. |
