ACE2 Monoclonal Antibody(Detector)
| 规格： | / 25μg / 100μg |
| 价格： | / ￥800 / ￥2100 |
货号：AN001680P
货期：咨询
宿主: Rat
反应性: H
应用: ELISA Detector
Overview
| Synonyms | ACEH;ACEII; |
| Swissprot | Q9BYF1 |
| Source | Rat |
| Reactivity | Human |
| Immunogen | Recombinant Human ACE2 protein expressed by Mammalian |
| Application | ELISA Detector |
| Recommended dilution | ELISA Detector,,0.1-0.4 μg/mL |
| Concentration | 1mg/mL |
| Clonality | Monoclonal |
Properties
| Clone No | 1G5 |
|---|---|
| Isotype | IgG2a |
| Purification | Protein A/G Purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at 4°C Valid for 1 month or -20°C Valid for 12 months,Avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions. |
| Storage buffer | Sterile PBS,pH 7.4 |
| Background | ACE2 (Angiotensin-converting enzyme 2),also named as ACEH,is a zinc metalloprotease of the ACE family and a critical regulator of the reninangiotensin system. ACE2 has a more restricted tissue distribution than ACE,being found predominantly in the heart,kidneys,and testes although low levels have been detected in a variety of tissues. ACE2 has been shown to be a functional receptor of the human coronaviruses SARS-CoV and SARS-CoV-2. The expression level and expression pattern of human ACE2 in different tissues might be critical for the susceptibility,symptoms,and outcome of 2019-nCoV/SARS-CoV-2 infection. It can be used as a potential therapeutic target of SARS-CoV-2. The calculated molecular weight of ACE2 is 92kDa but it migrates to 120kDa due to N-glycosylation . Sometimes,several cleaved fragments can also be detected as 75kDa,50 kDa or 37kDa. It has 2 isoforms produced by alternative splicing. This antibody is specific to ACE2. The location of ACE2 is membrane and cytoplasm,however it accumulates in the nucleus during the mitosis. |
