ACTN1 Polyclonal Antibody
| 规格： | / 60μL / 120μL / 200μL |
| 价格： | / ￥1380 / ￥2220 / ￥3300 |
货号：E-AB-70225
宿主: Rabbit
反应性: H,M,R
应用: WB
Overview
| Synonyms | actinin 1 smooth muscle,Actinin alpha 1,actinin,alpha 1,ACTN 1,Actn1,ACTN1,Alpha Actinin 1,Alpha actinin cytoskeletal isoform,Alpha-actinin cytoskeletal isoform,Alpha-actinin-1,BDPLT15,F actin cross linking protein,F-actin cross-linking protein,FLJ40884,FLJ54432,Non muscle alpha actinin 1,Non-muscle alpha-actinin-1,ACTN1抗体 |
| Swissprot | P12814,Q7TPR4,Q9Z1P2 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Recombinant protein corresponding to Mouseα-actinin1 |
| Application | WB(Detection kit: E-IR-R304) |
| Recommended dilution | WB,,1:1000-1:3000; |
| Concentration | 0.66 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane |
| Tissue specificity | Highest expression level in blood vessel layer |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol. |
| Background | Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene. |
