AF/LE Purified Anti-Human CD41 Antibody[HIP8]
| 规格： | |
| 价格： |
货号：E-AB-F10880P
货期：咨询
宿主: Mouse
反应性: H
应用: FCM
Overview
| Synonyms | antigen CD41;BDPLT16;BDPLT2;CD41;CD41B;form 2;GP2B;GPalpha IIb;GPIIb;GT;GTA;HPA3;Integrin alpha 2b;Integrin alpha IIb;Integrin alpha-IIb light chain;Integrin;alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex;antigen CD41);ITA2B;Itga2b;ITGAB;platelet fibrinogen receptor;alpha subunit;platelet glycoprotein IIb of IIb/IIIa complex;Platelet membrane glycoprotein IIb;platelet specific antigen BAK;PPP1R93 |
| Swissprot | P08514 |
| Source | Mouse |
| Reactivity | Human |
| Immunogen | Recombinant Human CD41 protein |
| Application | FCM |
| Recommended dilution | FCM,,2 μg/mL(1×10^5-5×10^5 cells) |
| Concentration | 1mg/mL |
| Clonality | Monoclonal |
Properties
| Clone No | HIP8 |
|---|---|
| Isotype | Mouse IgG1, κ |
| Purification | >98%, Protein A/G purified |
| Conjugation | Unconjugated |
| Storage instructions | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions. |
| Storage buffer | Sterile PBS. < 1.0 EU per mg of the antibody as determined by the LAL method |
| Background | The integrins are a superfamily of cell adhesion receptors that bind to extracellular matrix ligands,cell-surface ligands,and soluble ligands . They are transmembrane αβ heterodimers and at least 24 distinct integrin heterodimers are formed by the combination of 18 α and eight β known subunits . In addition to mediating cell adhesion,integrins also play important roles in modulating signal transduction pathways that control cellular responses including migration,proliferation,differentiation,and apoptosis . Integrin alpha-IIb (ITGA2B,CD41) is expressed on platelets,megakaryocytes and some hematopoietic progenitor cells . This protein undergoes post-translational cleavage to yield disulfide linked light and heavy chains which join with integrin beta3 (CD61) to form a receptor for fibronectin,fibrinogen,plasminogen,prothrombin,thrombospondin and vitronectin. Integrin alpha-IIb/beta-3 is crucial for platelet aggregation through binding of soluble fibrinogen. |
