AF/LE Purified Anti-Human CD8a Antibody[OKT-8]
| 规格： | / 50μg / 500μg / 1mg |
| 价格： | / ￥600 / ￥1960 / ￥3560 |
货号：E-AB-F11100
货期：咨询
宿主: Mouse
反应性: H
应用: FCM
Overview
| Synonyms | CD8A;MAL;T-cell surface glycoprotein CD8 alpha chain;T-lymphocyte differentiation antigen T8/Leu-2 |
| Swissprot | P01732 |
| Source | Mouse |
| Reactivity | Human |
| Immunogen | Recombinant Human CD8 protein |
| Application | FCM |
| Recommended dilution | FCM,,2 μg/mL(1×10^5-5×10^5 cells) |
| Concentration | 1mg/mL |
| Clonality | Monoclonal |
Properties
| Clone No | OKT-8 |
|---|---|
| Isotype | Mouse IgG2a, κ |
| Purification | >98%, Protein A/G purified |
| Conjugation | Unconjugated |
| Storage instructions | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions. |
| Storage buffer | Sterile PBS. < 1.0 EU per mg of the antibody as determined by the LAL method |
| Background | CD8a is a 32-34 kD type I glycoprotein. It forms a homodimer (CD8a/a) or heterodimer (CD8a/b) with CD8b. CD8, also known as T8 and Leu2, is a member of the immunoglobulin superfamily found on the majority of thymocytes, a subset of peripheral blood T cells, and NK cells (which express almost exclusively CD8a homodimers). CD8 acts as a co-receptor with MHC class I-restricted T cell receptors in antigen recognition and T cell activation and has been shown to play a role in thymic differentiation. Two domains in CD8a are important for function: the extracellular IgSF domain binds the α3 domain of MHC class I and the cytoplasmic CXCP motif binds the tyrosine kinase p56 Lck. |
