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AF/LE Purified Anti-Mouse CD22 Antibody[Cy34.1]

规格: / 50μg / 500μg / 1mg
价格: / ¥600 / ¥1960 / ¥3560

货号:E-AB-F10210

货期:咨询

宿主: Mouse

反应性: M

应用: FCM

  • 详情
  • Overview

    Synonyms Siglec2;B-cell receptor CD22;B-lymphocyte cell adhesion molecule;BL-CAM;CD22;Cd22;Lyb-8;Sialic acid-binding Ig-like lectin 2;Siglec-2;T-cell surface antigen Leu-14
    Swissprot P35329
    Source Mouse
    Reactivity Mouse
    Application FCM
    Concentration 0.5mg/mL
    Clonality Monoclonal

    Properties

    Clone No Cy34.1
    Isotype Mouse IgG1, κ
    Conjugation Unconjugated
    Storage instructions This product can be stored at 2-8°C for 12 months. Do not freeze.
    Storage buffer 0.2 μm filtered in PBS, pH 7.2. Azide Free (AF)/Low Endotoxin (LE): Contains no stabilizers or stabilizers. Endotoxin level is < 2 EU/mg as Determined by LAL gel clotting assay.
    Background The Cy34.1 monoclonal antibody specifically binds to the B-lymphocyte differentiation antigen CD22 on strains having the Lyb-8.2 alloantigen (e.g., A, BALB/c, CBA, C3H/He, C57BL, C57L, C58, SJL, SWR, but not AKR, DBA/1, DBA/2, NZB, PL). CD22 is expressed at high levels on mature peripheral B lymphocytes (follicular and marginal zone), B-1 cells (CD5+ B cells), and plasma cells. It is a member of the Ig gene superfamily and associates with the B-cell antigen receptor. Its sialic acid- binding immunoglobulin-like lectin (siglec) extracellular region mediates B-cell adhesion to ligands on endothelial cells in the bone marrow. Its intracellular domain is phosphorylated after cross-linking of antigen receptor or MHC class II antigen. It is involved in negative regulation of B-cell activation and protection from autoimmunity. B-cell proliferative responses to LPS or anti-mouse Ig µ chain are augmented in the presence of Cy34.1 mAb.
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