AGT Polyclonal Antibody
| 规格： | / 60μL / 120μL / 200μL |
| 价格： | / ￥1380 / ￥2220 / ￥3300 |
货号：E-AB-70276
宿主: Rabbit
反应性: M,R
应用: WB
Overview
| Synonyms | Aangiotensinogen (serpin peptidase inhibitor clade A member 8),AGT,AI265500,Alpha 1 antiproteinase antitrypsin,Ang,Ang I,Ang II,Ang III,AngII,Angiotensin I,Angiotensin II,Angiotensin III,Angiotensin-3,Angiotensinogen (PAT),Angiotensinogen,ANGT,ANHU,ANRT,AT-2,AT-II,Des-Asp[1]-angiotensin II,FLJ92595,FLJ97926,MGC105326,PAT,Pre angiotensinogen,Serine (or cysteine) proteinase inhibitor,Serpin A8,Serpin peptidase inhibitor clade A member 8,SERPINA8,AGT抗体 |
| Swissprot | P11859,P01015 |
| Source | Rabbit |
| Reactivity | Mouse,Rat |
| Immunogen | KLH conjugated Synthetic peptide corresponding to Mouse Angiotensinogen |
| Application | WB(Detection kit: E-IR-R304) |
| Recommended dilution | WB,,1:500-1:2000; |
| Concentration | 1.7 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Expressed by the liver and secreted in plasma. |
| Tissue specificity | Expressed by the liver and secreted in plasma.ighest expression level in liver. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol. |
| Background | Angiotensinogen is a precursor of angiotensin II (Ang II),is expressed and synthesized largely in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. It has a key role in mediating vascular constriction and regulating salt and fluid homeostasis. The resulting product,angiotensin I,is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. Mutations in this gene are associated with susceptibility to essential hypertension,and can cause renal tubular dysgenesis,a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation,and inflammatory bowel disease. |
