AIF1 Polyclonal Antibody
| 规格： | / 60μL / 120μL / 200μL |
| 价格： | / ￥1380 / ￥2220 / ￥3300 |
货号：E-AB-70324
宿主: Rabbit
反应性: M,R
应用: IHC
Overview
| Synonyms | AIF 1,AIF-1,Aif1,AIF1 protein,AIF1,Allograft inflammatory factor 1,Allograft inflammatory factor 1 splice variant G,allograft inflammatory factor-1 splice variant Hara-1,balloon angioplasty responsive transcription,BART 1,G1,G1 putative splice variant of allograft inflamatory factor 1,IBA 1,IBA1,interferon gamma responsive transcript,Interferon responsive transcript 1,interferon responsive transcript factor 1,Ionized calcium binding adapter molecule 1,Ionized calcium-binding adapter molecule 1,ionized calcium-binding adapter molecule,IRT 1,IRT1,Microglia response factor,MRF1,Protein g1,AIF1抗体 |
| Swissprot | O70200,P55009 |
| Source | Rabbit |
| Reactivity | Mouse,Rat |
| Immunogen | KLH conjugated Synthetic peptide corresponding to HumanIBA-1 |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:200-1:800 |
| Concentration | 1.6 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm>cytoskeleton. Cell projection>ruffle membrane. Associated with the actin cytoskeleton at membrane ruffles and at sites of phagocytosis. |
| Tissue specificity | Abundantly expressed in the testis, moderately in the spleen and lymph nodes and at low levels in the liver and thymus. Detected in macrophages.Highest expression level in testis. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol. |
| Background | This gene is induced by cytokines and interferon.Its protein product is thought to be involved in negative regulation of growth of vascular smooth muscle cells, which contributes to the anti-inflammatory response to vessel wall trauma.Three transcript variants encoding different isoforms have been found for this gene.Actin-binding protein that enhances membrane ruffling and RAC activation.Enhances the actin-bundling activity of LCP1.Binds calcium.Plays a role in RAC signaling and in phagocytosis.May play a role in macrophage activation and function.Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes.Enhances lymphocyte migration.Plays a role in vascular inflammation. |
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