AIFM1 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-40255
宿主: Rabbit
反应性: R
应用: WB
Overview
| Synonyms | AIFM1,AIFM1,Apoptosis inducing factor 1,mitochondrial,Apoptosis inducing factor,Apoptosis inducing factor,mitochondrion associated,1,Apoptosis-inducing factor 1,CMTX4,COWCK,COXPD6,Harlequin,Hq,mAIF,MGC111425,MGC5706,mitochondrial,Neuropathy,axonal motor-sensory,with deafness and mental retardation,neuropathy,axonal,motor-sensory with deafness and mental retardation (Cowchock syndrome),PDCD 8,PDCD8,Programmed cell death 8 (apoptosis inducing factor),Programmed cell death 8,Programmed cell death 8 isoform 1,Programmed cell death 8 isoform 2,Programmed cell death 8 isoform 3,Programmed cell death protein 8,Programmed cell death protein 8 mitochondrial,Programmed cell death protein 8 mitochondrial precursor,Programmed cell death protein 8 mitochondrial precursor,Striatal apoptosis inducing factor,AIFM1抗体 |
| Swissprot | Q9JM53 |
| Source | Rabbit |
| Reactivity | Rat |
| Immunogen | Recombinant Rat Apoptosis-inducing factor 1, mitochondrial protein |
| Application | WB(Detection kit: E-IR-R304) |
| Recommended dilution | WB,,1:500-1:1000; |
| Concentration | 1mg/mL |
Properties
| Cellular localization | Mitochondrion intermembrane space. Mitochondrion inner membrane. Cytoplasm. Nucleus. Cytoplasm>perinuclear region. Proteolytic cleavage during or just after translocation into the mitochondrial intermembrane space (IMS) results in the formation of an inner-membrane-anchored mature form (AIFmit). During apoptosis, further proteolytic processing leads to a mature form, which is confined to the mitochondrial IMS in a soluble form (AIFsol). AIFsol is released to the cytoplasm in response to specific death signals, and translocated to the nucleus, where it induces nuclear apoptosis. Colocalizes with EIF3G in the nucleus and perinuclear region. |
| Tissue specificity | Highest expression level in heart |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide,1% protective protein and 50% glycerol,pH7.4 |
| Background | This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells.Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation.In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9.Mutations in this gene cause combined oxidative phosphorylation deficiency 6, which results in a severe mitochondrial encephalomyopathy.Alternative splicing results in multiple transcript variants.A related pseudogene has been identified on chromosome 10. |
