本公司产品仅供体外研究使用,不用于临床诊断

AIFM1 Polyclonal Antibody

规格: / 60μL / 120μL / 200μL
价格: / ¥1380 / ¥2220 / ¥3300

货号:E-AB-70181

宿主: Rabbit

反应性: H,M,R

应用: IHC

  • 详情
  • Overview

    Synonyms AIFM1,AIFM1,Apoptosis inducing factor 1,mitochondrial,Apoptosis inducing factor,Apoptosis inducing factor,mitochondrion associated,1,Apoptosis-inducing factor 1,CMTX4,COWCK,COXPD6,Harlequin,Hq,mAIF,MGC111425,MGC5706,mitochondrial,Neuropathy,axonal motor-sensory,with deafness and mental retardation,neuropathy,axonal,motor-sensory with deafness and mental retardation (Cowchock syndrome),PDCD 8,PDCD8,Programmed cell death 8 (apoptosis inducing factor),Programmed cell death 8,Programmed cell death 8 isoform 1,Programmed cell death 8 isoform 2,Programmed cell death 8 isoform 3,Programmed cell death protein 8,Programmed cell death protein 8 mitochondrial,Programmed cell death protein 8 mitochondrial precursor,Programmed cell death protein 8 mitochondrial precursor,Striatal apoptosis inducing factor,AIFM1抗体
    Swissprot O95831,Q9Z0X1,Q9JM53
    Source Rabbit
    Reactivity Human,Mouse,Rat
    Immunogen KLH conjugated Synthetic peptide corresponding to Mouse AIF
    Application IHC(Detection kit: E-IR-R213)
    Recommended dilution IHC,,1:300-1:1000
    Concentration 0.98 mg/mL
    Clonality Polyclonal

    Properties

    Cellular localization Mitochondrion intermembrane space. Mitochondrion inner membrane. Cytoplasm. Nucleus. Cytoplasm>perinuclear region. Proteolytic cleavage during or just after translocation into the mitochondrial intermembrane space (IMS) results in the formation of an inner-membrane-anchored mature form (AIFmit). During apoptosis, further proteolytic processing leads to a mature form, which is confined to the mitochondrial IMS in a soluble form (AIFsol). AIFsol is released to the cytoplasm in response to specific death signals, and translocated to the nucleus, where it induces nuclear apoptosis. Colocalizes with EIF3G in the nucleus and perinuclear region.
    Tissue specificity Expressed in spleen, lymph node, thymus, peripheral blood leukocyte, bone marrow, cartilage, chondrocytes and fetal liver.Highest expression level in testis.
    Isotype IgG
    Purification Affinity purification
    Conjugation Unconjugated
    Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
    Storage buffer PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol.
    Background This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells.Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation.In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9.Mutations in this gene cause combined oxidative phosphorylation deficiency 6, which results in a severe mitochondrial encephalomyopathy.Alternative splicing results in multiple transcript variants.A related pseudogene has been identified on chromosome 10.
    如有任何问题,请拨打电话 027-87879180 或填写 在线留言 我们会第一时间联系您。
    ×
    var _hmt = _hmt || []; MIP.watch('count', function () { console.log("sdsfs"); _hmt.push(['_trackEvent', 'consult_mip', 'click', 'detail page']); })