AIM2 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-10974
宿主: Rabbit
反应性: H
应用: IHC
Overview
| Synonyms | Absent in melanoma 2,AIM 2,Aim2,AIM2,Interferon-inducible protein AIM2,OTTHUMP00000035296,PYHIN4,AIM2抗体 |
| Swissprot | O14862 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Recombinant protein of human AIM2 |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:50-1:200 |
| Concentration | 0.8 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Nucleus. |
| Tissue specificity | Expressed in spleen, small intestine, peripheral blood leukocytes, and testis. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | Interferon-inducible protein AIM2 (Absent in melanoma 2) is a 343 amino acid protein belonging to the HIN-200 family.Induced by IFN- , AIM2 is thought to act as a tumor suppressor by repressing NF B transcriptional activity.Localized to the nucleus, AIM2 contains one DAPIN domain and one HIN-200 domain.The DAPIN domain is composed mostly of -helixes and is a protein-protein interaction domain capable of binding other DAPIN domains.The HIN-200 domain has been shown to bind directly to DNA, which, along with the binding of another protein ASC, results in the activation of Caspase-1. |
