AKAP12 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-12884
宿主: Rabbit
反应性: H
应用: IHC
Overview
| Synonyms | A kinase (PRKA) anchor protein (gravin) 12,A kinase Anchor Protein 12,A kinase anchor protein 250kDa,A-kinase anchor protein 12,A-kinase anchor protein 250 kDa,AKA12,AKAP 12,AKAP 250,AKAP-12,Akap12,AKAP250,DKFZp686M0430,DKFZp686O0331,FLJ20945,FLJ97621,Gercelin,Gravin,Kinase scaffold protein gravin,Myasthenia gravis autoantigen,Myasthenia gravis autoantigen gravin,OTTHUMP00000017426,OTTHUMP00000017427,Src-Suppressed C Kinase Substrate,Srcs5,SSeCKS,Tsga12,AKAP12抗体 |
| Swissprot | Q02952 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Synthetic peptide of human AKAP12 |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:50-1:200 |
| Concentration | 0.4 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm>cell cortex. Cytoplasm>cytoskeleton. May be part of the cortical cytoskeleton. |
| Tissue specificity | Expressed in endothelial cells, cultured fibroblasts and osteosarcoma, but not in platelets, leukocytes, monocytic cell lines or peripherical blood cells. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed in endothelial cells, cultured fibroblasts, and osteosarcoma cells. It associates with protein kinases A and C and phosphatase, and serves as a scaffold protein in signal transduction. This protein and RII PKA colocalize at the cell periphery. This protein is a cell growth-related protein. Antibodies to this protein can be produced by patients with myasthenia gravis. Alternative splicing of this gene results in two transcript variants encoding different isoforms. |
