ALKBH2 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-10700
宿主: Rabbit
反应性: H,M
应用: WB
Overview
| Synonyms | 2OG Fe(II) oxy DC1,9530023G02,ABH 2,ABH2,alkB alkylation repair homolog 2,ALKB2,ALKBH2 alkB,ALKBH2,Alkylated DNA repair protein alkB homolog,Alkylated DNA repair protein alkB homolog 2,Alkylation repair homolog 2,Alpha ketoglutarate dependent dioxygenase alkB homolog 2,Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2,AU016977,DNA oxidative demethylase ALKBH2,EC 1.14.11.,FLJ99103,hABH2,mABH2,MGC90512,Oxy DC1,ALKBH2抗体 |
| Swissprot | Q6NS38 |
| Source | Rabbit |
| Reactivity | Human,Mouse |
| Immunogen | Recombinant protein of human ALKBH2 |
| Application | WB(Detection kit: E-IR-R304) |
| Recommended dilution | WB,,1:500-1:2000; |
| Concentration | 0.3 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Nucleus. Detected in replication foci during S-phase. |
| Tissue specificity | Detected in colon, small intestine, ovary, testis, prostate, skeletal muscle, heart, liver and urinary bladder. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 and ALKBH3 are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine. Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1-ethenoadenine (in vitro). Has strong preference for double-stranded DNA. Has low efficiency with single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron. |
