AMACR Polyclonal Antibody
| 规格： | / 50μL / 100μL |
| 价格： | / ￥1010 / ￥1640 |
货号：D-AB-10240L
货期：咨询
宿主: Rabbit
反应性: H
应用: WB,IHC
Overview
| Synonyms | 2 methylacyl CoA racemase, 2-methylacyl-CoA racemase, Alpha methylacyl CoA racemase, Alpha-methylacyl-CoA racemase, Amacr, AMACR, AMACRD, Macr1, RACE, RM |
| Swissprot | O09174 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Recombinant Mouse Amacr protein expressed by E.coli |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213) |
| Recommended dilution | WB,,1:1000-1:3000;IHC,,1:150-1:300; |
| Concentration | 1mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Mitochondrion, Peroxisome |
| Tissue specificity | Highest expressed in proximal tubule |
| Isotype | IgG |
| Purification | Antigen Affinity Purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide,1% protective protein and 50% glycerol,pH7.4 |
| Background | AMACR(Alpha-methylacyl-CoA racemase) belongs to the CaiB/BaiF CoA-transferase family. It is a mitochondrial and peroxisomal enzyme that catalyzes the conversion of 2R stereoisomers of phytanic and pristanic acid to their S counterparts. AMACR has previously been shown to be a highly sensitive marker for colorectal and clinically localized prostate cancer (PCa). However,AMACR expression is down-regulated at the transcript and protein level in hormone-refractory metastatic PCa,suggesting a hormone-dependent expression of AMACR. It has 3 isoforms produced by alternative splicing. Defects in AMACR are the cause of alpha-methylacyl-CoA racemase deficiency (AMACRD) and congenital bile acid synthesis defect type 4 (CBAS4). |
Images
Western Blot analysis of Rat kidney and Rat liver using AMACR Polyclonal Antibody at dilution of 1:3000.
Western Blot analysis of Rat intestine, Mouse kidney and Mouse liver using AMACR Polyclonal Antibody at dilution of 1:1000.
Immunohistochemistry of paraffin-embedded Mouse kidney using AMACR Polycloanl Antibody at dilution of 1:200.
Immunohistochemistry of paraffin-embedded Mouse kidney using AMACR Polycloanl Antibody at dilution of 1:200.
Immunohistochemistry of paraffin-embedded Human kidney using Amacr Polyclonal Antibody at dilution of 1:300
