AMIGO2 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-10790
宿主: Rabbit
反应性: H,M,R
应用: WB,IHC
Overview
| Synonyms | Adhesion molecule with Ig like domain 2,ALI 1,ALI1,Alivin 1,Alivin-1,Alivin1,AMGO2,AMIGO 2,AMIGO-2,Amigo2,Amphoterin induced gene 2,Amphoterin induced protein 2,Amphoterin-induced gene and open reading frame 2,Amphoterin-induced protein 2,DEGA,Differentially expressed in gastric adenocarcinoma,Differentially expressed in gastric adenocarcinomas,Transmembrane protein AMIGO 2,Transmembrane protein AMIGO2,AMIGO2抗体 |
| Swissprot | Q86SJ2 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Recombinant protein of human AMIGO2 |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213) |
| Recommended dilution | WB,,1:500-1:2000;IHC,,1:50-1:200; |
| Concentration | 0.5 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cell membrane. Nucleus. Associated with nucleus as well as plasma membrane. Restricted to somata of cerebellar as well as hippocampal neurons. |
| Tissue specificity | Highest levels in breast, ovary, cervix, and uterus. Lower levels in lung, colon, and rectum. Differentially expressed in 56% of thyroid, 57% of pancreatic and 45% of stomach cancers. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | The amphoterin-induced gene and ORF (AMIGO) family of proteins consists of AMIGO-1, AMIGO-2 and AMIGO-3. All three members are single pass type I membrane proteins that contain several leucine-rich repeats, one IgG domain, and a transmembrane domain. The AMIGO proteins are specifically expressed on fiber tracts of neuronal tissues and participate in their formation. The AMIGO proteins can form complexes with each other, but can also bind itself. AMIGO-1, also designated Alivin-2, promotes growth and fasciculation of neurites and plays a role in myelination and fasciculation of developing neural axons. In cerebellar neurons, AMIGO-2 (Alivin-1) is crucial for depolarization-dependent survival. Similar to AMIGO-1 and AMIGO-2, AMIGO-3 (Alivin-3) plays a role in homophilic and/or heterophilic cell-cell interaction and signal transduction |
Images
Western Blot analysis of SP20 cell and Mouse heart tissue using AMIGO2 Polyclonal Antibody at dilution of 1:615
Immunohistochemistry of paraffin-embedded Human esophagus cancer using AMIGO2 Polyclonal Antibody at dilution of 1:50
Immunohistochemistry of paraffin-embedded Human breast cancer using AMIGO2 Polyclonal Antibody at dilution of 1:50
