API5 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-16168
宿主: Rabbit
反应性: H
应用: WB
Overview
| Synonyms | AAC 11,AAC-11,AAC11,Antiapoptosis clone 11 protein,API 5,API-5,api5,API5 like 1,API5,API5L1,Apoptosis inhibitor 5,Cell migration inducing gene 8 protein,Cell migration-inducing gene 8 protein,Fibroblast growth factor 2 interacting factor 2,Fibroblast growth factor 2-interacting factor,FIF,MIG 8,MIG8,Migration inducing protein MIG8,Protein XAGL,API5抗体 |
| Swissprot | Q9BZZ5 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Synthetic peptide of human API5 |
| Application | WB(Detection kit: E-IR-R304) |
| Recommended dilution | WB,,1:500-1:2000; |
| Concentration | 1.1 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm and Nucleus. Cytoplasm. Mainly nuclear. Can also be cytoplasmic. |
| Tissue specificity | Expressed in all tissues tested, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highest levels in heart, pancreas and placenta. Highly expressed in several cancers. Preferentially expressed in squamous cell carcinoma versus adenocarcinoma in non-small cell lung cancer. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | This gene encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation. This protein suppresses the transcription factor E2F1-induced apoptosis and also interacts with, and negatively regulates Acinus, a nuclear factor involved in apoptotic DNA fragmentation. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. |
