APTX Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-10820
宿主: Rabbit
反应性: H,M,R
应用: IHC
Overview
| Synonyms | AOA 1,AOA,AOA1,Aprataxin,Aprataxin homolog,Aptx,APTX,Ataxia 1 early onset with hypoalbuminemia,Ataxia1 early onset with hypoalbuminemia,AXA 1,AXA1,EAOH,EOAHA,FHA HIT,FHA-HIT,FLJ20157,Forkhead associated domain histidine triad like,Forkhead associated domain histidine triad like protein,Forkhead-associated domain histidine triad-like protein,MGC1072,APTX抗体 |
| Swissprot | Q7Z2E3 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Recombinant protein of human APTX |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:50-1:200 |
| Concentration | 0.5 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Nucleus>nucleoplasm. Nucleus>nucleolus. Upon genotoxic stress, colocalizes with XRCC1 at sites of DNA damage. Colocalizes with MDC1 at sites of DNA double-strand breaks. Interaction with NCL is required for nucleolar localization. |
| Tissue specificity | Widely expressed. In brain, it is expressed in the posterior cortex, cerebellum, hippocampus and olfactory bulb. Isoform 1 is highly expressed in the cerebral cortex and cerebellum, compared to isoform 2. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | This gene encodes a member of the histidine triad (HIT) superfamily. The encoded protein may play a role in single-stranded DNA repair through its nucleotide-binding activity and its diadenosine polyphosphate hydrolase activity. Mutations in this gene have been associated with ataxia-ocular apraxia. Alternatively spliced transcript variants have been identified for this gene. |
