ARC Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-10826
宿主: Rabbit
反应性: H
应用: IHC
Overview
| Synonyms | activity regulated cytoskeleton associated protein,activity regulated gene 3.1 protein homolog,Activity-regulated cytoskeleton-associated protein,Activity-regulated gene 3.1 protein homolog,Arc,ARC/ARG3.1,ARC,Arg3.1,ARC抗体 |
| Swissprot | Q7LC44 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Recombinant protein of human ARC |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:50-1:200 |
| Concentration | 0.5 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm>cytoskeleton. Endosome. Cytoplasmic vesicle>secretory vesicle>acrosome. Cell junction>synapse>postsynaptic cell membrane>postsynaptic density. Cell projection>dendrite. Cell projection>dendritic spine. Cell junction>synapse. Associated with the cell cortex of neuronal soma and dendrites. Enriched in postsynaptic density of dendritic spines. Associated with the sperm tail (By similarity). Enriched on the plasma membrane. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | Arc (for activity-regulated cytoskeleton-associated protein) is a growth factor and immediate early gene that is enriched in brain. Arc mRNA and protein levels are induced by neuronal activity, which is necessary to stimulate neuroplasticity, indicating a potential role for Arc in activity-dependent changes in dendrite function. Arc expression has been detected in neuronal cell bodies and dendrites in the hippocampus, amygdala, hypothalamus, striatum and cortex. Arc has been shown to localize to the cytoskeleton of neuronal cells and appears to colocalize with F-Actin, although it may associate with an Actin-associated protein rather than directly with F-Actin. It has been shown that cocaine-stimulated neuronal activity results in increased Arc mRNA levels in striatum. |
