ARIH2 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-12985
宿主: Rabbit
反应性: H,M
应用: WB
Overview
| Synonyms | HT005,all trans retinoic acid inducible RING finger,Ari 2,Ari-2,ARI2,ARI2,Ariadne 2,Ariadne 2 protein homolog,ariadne homolog 2 (Drosophila),ariadne homolog 2,Ariadne RBR E3 ubiquitin protein ligase 2,ARIH 2,Arih2,E3 ubiquitin protein ligase ARIH2,E3 ubiquitin-protein ligase ARIH2,protein ariadne 2 homolog,Protein ariadne-2 homolog,Triad 1,TRIAD1,Triad1 protein,UIP48,ARIH2抗体 |
| Swissprot | O95376 |
| Source | Rabbit |
| Reactivity | Human,Mouse |
| Immunogen | Synthetic peptide of human ARIH2 |
| Application | WB(Detection kit: E-IR-R304) |
| Recommended dilution | WB,,1:500-1:2000; |
| Concentration | 0.6 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Nucleus. Cytoplasm. |
| Tissue specificity | Widely expressed with higher expression in granulocytes. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | TRIAD1, also known as ARIH2 (ariadne homolog 2) or ARI2, is a 493 amino acid protein that contains one IBR-type zinc finger and two RING-type zinc fingers and belongs to the ariadne subfamily of RBR proteins. Localized to the nucleus, TRIAD1 interacts with UBE2L3 and is thought to act as an E3 ubiquitin-protein ligase, functioning to accept ubiquitin from E2 ubiquitin-conjugating enzymes and transfer the acquired ubiquitin residue to target substrates. TRIAD1 is subject to post-translational DNA damage-dependent phosphorylation, probably by ATM or ATR. The gene encoding TRIAD1 maps to human chromosome 3, which houses over 1,100 genes, including a chemokine receptor (CKR) gene cluster and a variety of human cancer-related gene loci. |
