ARL2BP Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-52822
宿主: Rabbit
反应性: H,M,R
应用: IHC
Overview
| Synonyms | ADP ribosylation factor like 2 binding protein,ADP-ribosylation factor-like protein 2-binding protein,AR2BP,Arf like 2 binding protein BART1,ARF-like 2-binding protein,ARL2 binding protein,Arl2bp,ARL2BP protein,BART,BART1,Binder of ARF2 protein 1,Binder of Arl Two,Binder of Arl2,Retinitis pigmentosa 66 (autosomal recessive),RP66,ARL2BP抗体 |
| Swissprot | Q9Y2Y0 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Fusion protein of human ARL2BP |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:20-1:100 |
| Concentration | 0.84mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm. Mitochondrion intermembrane space. Cytoplasm>cytoskeleton>centrosome. Nucleus. Cytoplasm>cytoskeleton>spindle. The complex formed with ARL2BP, ARL2 and SLC25A4 is expressed in mitochondria (By similarity). Detected in the midbody matrix. Not detected in the Golgi, nucleus and on the mitotic spindle. Centrosome-associated throughout the cell cycle. Not detected to interphase microtubules. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | ADP-ribosylation factor (ARF)-like proteins (ARLs) comprise a functionally distinct group of the ARF family of RAS-related GTPases. The protein encoded by this gene binds to ARL2.GTP with high affinity but does not interact with ARL2.GDP, activated ARF, or RHO proteins. The lack of detectable membrane association of this protein or ARL2 upon activation of ARL2 is suggestive of actions distinct from those of the ARFs. This protein is considered to be the first ARL2-specific effector identified, due to its interaction with ARL2.GTP but lack of ARL2 GTPase-activating protein activity.ARL2BP (ADP Ribosylation Factor Like GTPase 2 Binding Protein) is a Protein Coding gene. Diseases associated with ARL2BP include Retinitis Pigmentosa With Or Without Situs Inversus and Arl2bp-Related Retinitis Pigmentosa. Among its related pathways are Integration of energy metabolism and Metabolism. GO annotations related to this gene include transcription coactivator activity and GTPase regulator activity. |
