ATG16L1 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-19375
宿主: Rabbit
反应性: H,M
应用: WB,IHC
Overview
| Synonyms | A16L1,APG16 like 1,APG16-like 1,APG16L,APG16L beta,ATG16 autophagy related 16 like 1,ATG16 autophagy related 16-like 1 (S. cerevisiae),ATG16A,ATG16L,Atg16l1,Autophagy related protein 16 1,Autophagy-related protein 16-1,FLJ00045,FLJ10035,FLJ10828,FLJ22677,IBD10,OTTHUMP00000164391,OTTHUMP00000164393,OTTHUMP00000165876,OTTHUMP00000165877,WD repeat domain 30,WDR30,ATG16L1抗体 |
| Swissprot | Q676U5 |
| Source | Rabbit |
| Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human ATG16L1 |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213) |
| Recommended dilution | WB,,1:500-1:2000;IHC,,1:30-1:150; |
| Concentration | 0.9mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm. Preautophagosomal structure membrane. Recruited to omegasomes membranes by WIPI2. Omegasomes are endoplasmic reticulum connected strutures at the origin of preautophagosomal structures. Localized to preautophagosomal structure (PAS) where it is involved in the membrane targeting of ATG5. Localizes also to discrete punctae along the ciliary axoneme. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | ATG16L1 (Autophagy Related 16 Like 1) is a Protein Coding gene. Diseases associated with ATG16L1 include Inflammatory Bowel Disease 10 and Inflammatory Bowel Disease. Among its related pathways are Autophagy Pathway and Senescence and Autophagy in Cancer. GO annotations related to this gene include identical protein binding. An important paralog of this gene is ATG16L2.The protein encoded by this gene is part of a large protein complex that is necessary for autophagy, the major process by which intracellular components are targeted to lysosomes for degradation. Defects in this gene are a cause of susceptibility to inflammatory bowel disease type 10 (IBD10). Several transcript variants encoding different isoforms have been found for this gene. |
Images
Western blot analysis of Raji cell using ATG16L1 Polyclonal Antibody at dilution of 1:600
Immunohistochemistry of paraffin-embedded Human breast cancer tissue using ATG16L1 Polyclonal Antibody at dilution of 1:40(×200)
Immunohistochemistry of paraffin-embedded Human gastric cancer tissue using ATG16L1 Polyclonal Antibody at dilution of 1:40(×200)
