ATP7A Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-16268
宿主: Rabbit
反应性: H,M,R
应用: IHC
Overview
| Synonyms | ATP 7A,ATP7A,ATP7A,ATPase copper transporting alpha polypeptide,ATPase Cu++ transporting alpha polypeptide (Menkes syndrome),ATPase Cu++ transporting alpha polypeptide,Copper pump 1,Copper transporting ATPase 1,Copper-transporting ATPase 1,Cu++ transporting P type ATPase,DSMAX,FLJ17790,MC 1,MC1,Menkes disease associated protein,Menkes disease-associated protein,Menkes syndrome,MK,MNK,OHS,OTTHUMP00000062077,SMAX3,ATP7A抗体 |
| Swissprot | Q04656 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Synthetic peptide of human ATP7A |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:50-1:200 |
| Concentration | 0.5mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Endoplasmic reticulum; Cytoplasm>cytosol and Golgi apparatus>trans-Golgi network membrane. Cell membrane. Cycles constitutively between the trans-Golgi network (TGN) and the plasma membrane. Predominantly found in the TGN and relocalized to the plasma membrane in response to elevated copper levels. |
| Tissue specificity | Found in most tissues except liver. Isoform 3 is widely expressed including in liver cell lines. Isoform 1 is expressed in fibroblasts, choriocarcinoma, colon carcinoma and neuroblastoma cell lines. Isoform 2 is expressed in fibroblasts, colon carcinoma and neuroblastoma cell lines. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | This gene encodes a transmembrane protein that functions in copper transport across membranes. This protein is localized to the trans Golgi network, where it is predicted to supply copper to copper-dependent enzymes in the secretory pathway. It relocalizes to the plasma membrane under conditions of elevated extracellular copper, and functions in the efflux of copper from cells. Mutations in this gene are associated with Menkes disease, X-linked distal spinal muscular atrophy, and occipital horn syndrome. Alternatively-spliced transcript variants have been observed. |
