BAFFR/TNFRSF13C Polyclonal Antibody
| 规格： | / 25μL / 100μL |
| 价格： | / ￥800 / ￥2100 |
货号：D-AB-10443L
货期：咨询
宿主: Rabbit
反应性: R
应用: WB
Overview
| Synonyms | Tumor necrosis factor receptor superfamily member 13C;B-cell-activating factor receptor;BAFF receptor (BAFF-R);BLyS receptor 3;TNFRSF13C;BAFFR;BR3 |
| Swissprot | Q96RJ3 |
| Source | Rabbit |
| Reactivity | Rat |
| Immunogen | Recombinant Human BAFFR/TNFRSF13C protein expressed by Mammalian |
| Application | WB(Detection kit: E-IR-R304) |
| Recommended dilution | WB,,1:500-1:1000 |
| Concentration | 1mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Membrane |
| Isotype | IgG |
| Purification | Antigen Affinity Purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide,1% BSA and 50% glycerol,pH7.4 |
| Background | Tumor necrosis factor receptor superfamily,member 13C (TNFRSF13C) also known as B-cell-activating factor receptor (BAFFR) and CD268 antigen,is a member of the tumor necrosis factor receptor superfamily. BAFF promotes the survival of B cells and is essential for B cell maturation. BAFF binds to three TNF receptor superfamily members: B-cell maturation antigen (BCMA/TNFRSF17),transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI/TNFRSF13B) and BAFF receptor (BAFF R/BR3/TNFRSF13C). These receptors are type III transmembrane proteins that lack a signal peptide. BAFF R is highly expressed in spleen,lymph node and resting B cells. It is also expressed at lower levels in activated B cell,in resting CD4+ T cells,in thymus and peripheral blood leukocytes. BAFF knockout mice lack mature B cells. Similarly,A/WySnJ mice that are defective in BAFF-R intracellular signaling also lack mature B cells,suggesting that BAFF R is the critical receptor for BAFF during B lymphopoiesis. It has been proposed that abnormally high levels of BAFFR/TNFRSF13C (CD268) may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. |
