BBC3 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-15523
宿主: Rabbit
反应性: H
应用: WB
Overview
| Synonyms | BBC 3,Bbc3,BBC3,BCL 2 binding component 3,Bcl-2-binding component 3,BCL2 binding component 3,JFY 1,JFY-1,JFY1,p53 up regulated modulator of apoptosis,p53 up-regulated modulator of apoptosis,p53 Upregulated Modulator of Apoptosis,PUMA alpha,PUMA/JFY1,BBC3抗体 |
| Swissprot | Q9BXH1 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Synthetic peptide of human BBC3 |
| Application | WB(Detection kit: E-IR-R304) |
| Recommended dilution | WB,,1:200-1:1000; |
| Concentration | 0.9 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Mitochondrion. Localized to the mitochondria in order to induce cytochrome c release. |
| Tissue specificity | Ubiquitously expressed. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. |
