BCAS3 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-18703
宿主: Rabbit
反应性: H,M
应用: WB,IHC
Overview
| Synonyms | 1500019F07Rik,2610028P08Rik,AU021018,BC028339,BCAS3,BCAS3,Breast carcinoma-amplified sequence 3,FLJ20128,GAOB1,K20D4,MAAB,Maab1 protein,MGC4973,rudhira,BCAS3抗体 |
| Swissprot | Q9H6U6 |
| Source | Rabbit |
| Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human BCAS3 |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213) |
| Recommended dilution | WB,,1:500-1:2000;IHC,,1:30-1:150; |
| Concentration | 1.26mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Nucleus. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | BCAS3 (breast carcinoma amplified sequence 3), also designated MAAB or GAOB1, is a 913 amino acid protein that is believed to be involved in breast cancer progression.The gene is regulated by ER (estrogen receptor alpha) and expressed in multiple tissues, including malignant human brain lesions.It is overexpressed and amplified in breast cancer cell lines.BCAS3 contains three WD40 repeat regions, a bromodomain, a rare zinc-finger motif, four probable DNA-binding domains, and two kinase-inducible phosphorylation domains.Five variants are produced due to alternative splicing.BCAS3 interacts with histone H3 and PCAF, which is indicative of histone acetyltransferase activity.BCAS3 also exhibits ER transactiviation activity by acting as a coactivator with PELP1 or MTA1.The amplification and translocation between the BCAS3 gene and the BCAS4 gene results in a fusion transcript is overexpressed in MCF-7 cells. |
Images
Western blot analysis of 293T cell lysates using BCAS3 Polyclonal Antibody at dilution of 1:500
Immunohistochemistry of paraffin-embedded Human lung cancer tissue using BCAS3 Polyclonal Antibody at dilution of 1:35(×200)
Immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using BCAS3 Polyclonal Antibody at dilution of 1:35(×200)
