BCR Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-40431
宿主: Rabbit
反应性: H,M,R
应用: WB,IHC
Overview
| Synonyms | ALL, bcr, BCR1, Breakpoint cluster region, CML, D22S11, D22S662, PHL, Renal carcinoma antigen NY-REN-26,BCR抗体 |
| Swissprot | Q6PAJ1 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Recombinant Mouse Breakpoint cluster region protein |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213) |
| Recommended dilution | WB 1:500-1:2000 IHC 1:50-1:200 |
| Concentration | 1mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cell junction, Cell projection, Synapse |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% Proclin300, 50% glycerol, pH7.3. |
| Background | A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. |
Images
Western Blot analysis of Rat brain using BCR Polyclonal Antibody at dilution of 1:1000
Immunohistochemistry of paraffin-embedded Human liver using BCR Polycloanl Antibody at dilution of 1:200
Immunohistochemistry of paraffin-embedded Human bladder cancer using BCR Polycloanl Antibody at dilution of 1:200
Immunohistochemistry of paraffin-embedded Mouse brain using BCR Polycloanl Antibody at dilution of 1:200
Immunohistochemistry of paraffin-embedded Mouse kidney using BCR Polycloanl Antibody at dilution of 1:200
