BECN1 Monoclonal Antibody
| 规格： | / 20μL / 60μL / 120μL |
| 价格： | / ￥580 / ￥1420 / ￥2310 |
货号：E-AB-22238
宿主: Mouse
反应性: H,M,R
应用: IHC-p
Overview
| Synonyms | APG6,ATG 6,ATG6,ATG6 autophagy related 6 homolog,Bcl-2-interacting protein beclin,Beclin 1 (coiled coil moesin like BCL2 interacting protein),Beclin 1 autophagy related,Beclin-1,Beclin1,BECN 1,Becn1,BECN1,Coiled coil myosin like BCL2 interacting protein,Coiled-coil myosin-like BCL2-interacting protein,GT197,Protein GT197,VPS 30,VPS30,Beclin-1 Mouse (5A11)抗体 |
| Swissprot | Q14457 |
| Source | Mouse |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Synthetic Peptide of Beclin-1 |
| Application | IHC-p(Detection kit: E-IR-R213) |
| Recommended dilution | IHC 1:100-200 |
| Concentration | 1mg/mL |
| Clonality | Monoclonal |
Properties
| Cellular localization | Golgi apparatus>trans-Golgi network membrane. Interaction with ATG14 promotes translocation to autophagosomes. Expressed in dendrites and cell bodies of cerebellar Purkinje cells. |
| Tissue specificity | Ubiquitous. |
| Clone No | Clone:5A11 |
|---|---|
| Isotype | IgG |
| Purification | Protein A purification |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide,0.5% BSA and 50% glycerol pH 7.4. |
| Background | Beclin-1 (BECN1), also known as ATG6 or VPS30, has a central role in autophagy, a process of programmed cell survival, which is increased during periods of cell stress and extinguished during the cell cycle. Beclin-1, may play a role in antiviral host defense. It protects against infection by a neurovirulent strain of Sindbis virus. Beclin-1 participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration. A progressively reduced Beclin-1 expression is reported to correlate with the primary tumor growth of squamous cell carcinoma and adenocarcinoma of the lung. Caspase-mediated cleavage of Beclin 1 promotes crosstalk between apoptosis and autophagy. |
