BLNK Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-16280
宿主: Rabbit
反应性: H,M,R
应用: IHC
Overview
| Synonyms | AGM4,B cell adapter containing SH2 domain protein,B cell adapter containing Src homology 2 domain protein,B cell adaptor containing SH2 domain,B cell linker,B cell linker protein,B cell-specific adaptor protein,B-cell activation,B-cell adapter containing a SH2 domain protein,B-cell adapter containing a Src homology 2 domain protein,B-cell linker protein,BASH,Bca,BLNK,BLNK s,BLNK,Cytoplasmic adapter protein,Ly 57,Ly57,Lymphocyte antigen 57,Lyw 57,Lyw57,MGC111051,SH2 domain-containing leukocyte protein,65-KD,SLP 65,SLP-65,SLP65,Src homology [SH2] domain-containing leukocyte protein of 65 kD,Src homology 2 domain containing leukocyte protein of 65 kDa,Src homology 2 domain-containing leukocyte protein of 65 kDa,BLNK抗体 |
| Swissprot | Q8WV28 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Synthetic peptide of human BLNK |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | WB,,1:500-1:2000;IHC,,1:50-1:200; |
| Concentration | 0.6mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm. Cell membrane. BCR activation results in the translocation to membrane fraction. |
| Tissue specificity | Expressed in B-cell lineage and fibroblast cell lines (at protein level). Highest levels of expression in the spleen, with lower levels in the liver, kidney, pancreas, small intestines and colon. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development.This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions.The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation.Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked.Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. |
