BSG Polyclonal Antibody
| 规格： | / 60μL / 120μL / 200μL |
| 价格： | / ￥1380 / ￥2220 / ￥3300 |
货号：E-AB-70271
宿主: Rabbit
反应性: H,M,R
应用: IHC
Overview
| Synonyms | 5A11 antigen,5F7,BASI,Basigin (Ok blood group),Basigin,Blood brain barrier HT7 antigen,Bsg,CD 147,CD147,CD147 antigen,Collagenase stimulatory factor,EMMPRIN,Extracellular matrix metalloproteinase inducer,Leukocyte activation antigen M6,M 6,M6,M6 leukocyte activation antigen,Neurothelin,OK,OK blood group,OK blood group antigen,TCSF,Tumor cell derived collagenase stimulatory factor,Tumor cell-derived collagenase stimulatory factor,BSG抗体 |
| Swissprot | P35613,P18572,P26453 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Recombinant protein corresponding to Mouse CD147 |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:200-1:500 |
| Concentration | 370 μg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cell membrane. Melanosome. Colocalizes with SLC16A1 and SLC16A8 (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV. |
| Tissue specificity | Present only in vascular endothelium in non-neoplastic regions of the brain, whereas it is present in tumor cells but not in proliferating blood vessels in malignant gliomas.Highest expression level in apex of heart. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol. |
| Background | BSG,also named as 5F7,Basigin,EMMPRIN,TCSF and CD147,plays pivotal roles in spermatogenesis,embryo implantation,neural network formation and tumor progression. It stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS).CD147 may target monocarboxylate transporters SLC16A1,SLC16A3 and SLC16A8 to plasma membranes of retinal pigment epithelium and neural retina. It seems to be a receptor for oligomannosidic glycans. CD147 is a receptor of CypA,inducing matrix metalloproteinase expression and mediating the degradation of the extracellular matrix,plays an important role in tumorigenesis and invasion in oral cancer. It has been considered as an objective and effective marker to predict invasion and prognosis in various cancers. |
Images
Immunohistochemistry analysis of paraffin-embedded human lung cancer using BSG Polyclonal Antibody at dilution of 1:200.
Immunohistochemistry analysis of paraffin-embedded human colon cancer using BSG Polyclonal Antibody at dilution of 1:200.
Immunohistochemistry analysis of paraffin-embedded rat spleen using BSG Polyclonal Antibody at dilution of 1:200.
Immunohistochemistry analysis of paraffin-embedded Mouse kidney using BSG Polyclonal Antibody at dilution of 1:200.
