C12orf5 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-16101
宿主: Rabbit
反应性: H
应用: IHC
Overview
| Synonyms | 6-bisphosphatase TIGAR,C12ORF5,chromosome 12 open reading frame 5,FR2BP,Fructose-2,6-bisphosphatase TIGAR,Fructose-2,6-bisphosphate 2-phosphatase,Probable fructose 2,6 bisphosphatase TIGAR,Probable fructose-2,tigar,TIGAR,TP53 induced glycolysis and apoptosis regulator,TP53 induced glycolysis regulatory phosphatase,TP53-induced glycolysis and apoptosis regulator,Transactivated by NS3TP2 protein,C12orf5抗体 |
| Swissprot | Q9NQ88 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Synthetic peptide of human C12orf5 |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:100-1:300 |
| Concentration | 0.4 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytosol,Mitochondrion,mitochondrial outer membrane,Nucleus,Other locations:cytoplasm,intracellular |
| Tissue specificity | Expressed in the brain (PubMed:22887998). Expressed in breast tumors (PubMed:21820150). Expressed in glioblastomas (PubMed:22887998). |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | This gene is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate. The protein functions by blocking glycolysis and directing the pathway into the pentose phosphate shunt. Expression of this protein also protects cells from DNA damaging reactive oxygen species and provides some protection from DNA damage-induced apoptosis. The 12p13.32 region that includes this gene is paralogous to the 11q13.3 region. |
