C14orf169 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-17743
宿主: Rabbit
反应性: H,M,R
应用: IHC
Overview
| Synonyms | 60S ribosomal protein L8 histidine hydroxylase,C14orf169,Chromosome 14 open reading frame 169 ,Histone lysine demethylase NO66,hsNO66,Hypothetical protein FLJ21802,Lysine-specific demethylase NO66,MAPJD,MYC associated protein with JmjC domain,NO66,NO66,Nucleolar protein 66,Ribosomal oxygenase NO66,ROX,Up regulated in lung cancer 2,URLC2,C14orf169抗体 |
| Swissprot | Q9H6W3 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Synthetic peptide of human C14orf169 |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:30-1:150 |
| Concentration | 0.8mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Nucleus>nucleolus. Nucleus>nucleoplasm. Granular part of nucleoli. Nucleoplasm, nucleoplasmic foci, some of them associated with nucleoli. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216'. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation (By similarity). May also play a role in ribosome biogenesis and in the replication or remodeling of certain heterochromatic region. Participates in MYC-induced transcriptional activation. |
