C15orf23 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-40192
宿主: Rabbit
反应性: H
应用: WB
Overview
| Synonyms | KNSTRN,C15orf23,chromosome 15 open reading frame 23,HSD11,Kinastrin,Kinetochore-localized astrin-binding protein,Kinetochore-localized astrin/SPAG5-binding protein,Putative TRAF4-associated factor 1,SKAP,small kinetochore associated protein,T4AF1,TRAF4 associated factor 1,TRAF4-associated factor 1,Traf4af1,C15orf23抗体 |
| Swissprot | Q9Y448 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Recombinant Human Small kinetochore-associated protein protein |
| Application | WB(Detection kit: E-IR-R304) |
| Recommended dilution | WB,,1:500-1:2000; |
| Concentration | 2mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore, Microtubule, Nucleus |
| Tissue specificity | Widely expressed, including in skin. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide,1% protective protein and 50% glycerol,pH7.4 |
| Background | Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase . Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments. Required for kinetochore oscillations and dynamics of microtubule plus-ends during live cell mitosis, possibly by forming a link between spindle microtubule plus-ends and mitotic chromosomes to achieve faithful cell division. |
