CASP4 Polyclonal Antibody
| 规格： | / 25μL / 100μL |
| 价格： | / ￥800 / ￥2100 |
货号：D-AB-10447L
货期：咨询
宿主: Rabbit
反应性: H,M
应用: IHC,IF
Overview
| Synonyms | Apoptotic cysteine protease Mih1/TX;CASP-4;CASP4;CASP4;Caspase 4 apoptosis related cysteine peptidase;Caspase-4 subunit 2;Caspase4;ICE(rel)-II;ICE(rel)II;ICEREL II;ICH2;Mih1/TX;Protease ICH-2;Protease TX;TX |
| Swissprot | P49662 |
| Source | Rabbit |
| Reactivity | Human,Mouse |
| Immunogen | Recombinant Human CASP4 protein expressed by E.coli |
| Application | IHC(Detection kit: E-IR-R213),IF |
| Recommended dilution | IHC,,1:400-1:800;IF,,1:50-1:200 |
| Concentration | 1mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytosol;AIM2 inflammasome complex;cytosol;IPAF inflammasome complex;NLRP3 inflammasome complex;Endoplasmic reticulum;endoplasmic reticulum;endoplasmic reticulum membrane;Extracellular region or secreted;extracellular region;Mitochondrion;Plasma Membrane;Other locations:protein complex |
| Isotype | IgG |
| Purification | Antigen Affinity Purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide,1% BSA and 50% glycerol,pH7.4 |
| Background | This gene encodes a member of the cysteine proteases that plays important roles in apoptosis,cell migration and the inflammatory response. The encoded protein mediates production of pro-inflammatory cytokines by macrophages upon bacterial infection. Mice lacking the encoded protein are resistant to endotoxic shock induced by lipopolysaccharide. A 5-bp deletion encompassing a splice acceptor junction resulting in alternate splicing and a shorter non-functional isoform in certain mouse strains has been described. Although its official nomenclature is "caspase 4,apoptosis-related cysteine peptidase",this gene and its encoded protein have historically been called caspase 11. This gene is present in a cluster of three caspase genes on chromosome 9. |
Images
Immunohistochemistry of paraffinembedded Human tonsil using CASP4 Polyclonal Antibody at dilution of 1:800
Immunohistochemistry of paraffinembedded Human colon cancer using CASP4 Polyclonal Antibody at dilution of 1:800
Immunofluorescence analysis of NIH-3T3 cells using CASP4 Polyclonal Antibody at dilution of 1:200
