Catenin beta Polyclonal Antibody
| 规格： | / 60μL / 120μL / 200μL |
| 价格： | / ￥1380 / ￥2220 / ￥3300 |
货号：E-AB-70005
宿主: Rabbit
反应性: H,M,R
应用: WB,IHC,IF
Overview
| Synonyms | Beta catenin,Beta-catenin,Cadherin associated protein,Catenin (cadherin associated protein),beta 1,88kDa,Catenin beta 1,Catenin beta-1,CATNB,CHBCAT,CTNB1,CTNNB,CTNNB1,DKFZp686D02253,FLJ25606,FLJ37923,OTTHUMP00000162082,OTTHUMP00000165222,OTTHUMP00000165223,OTTHUMP00000209288,OTTHUMP00000209289,Catenin beta抗体 |
| Swissprot | P35222,Q02248,Q9WU82 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | KLH conjugated Synthetic peptide corresponding to Mouse β-catenin |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213),IF |
| Recommended dilution | WB,,1:500-1:2000;IHC,,1:300-1:1000;IF,,1:200-1:800; |
| Concentration | 0.97 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm. Nucleus. Cytoplasm>cytoskeleton. Cell junction>adherens junction. Cell junction. Cell membrane. Cytoplasmic when it is unstabilized (high level of phosphorylation) or bound to CDH1. Translocates to the nucleus when it is stabilized (low level of phosphorylation). Interaction with GLIS2 and MUC1 promotes nuclear translocation. Interaction with EMD inhibits nuclear localization. |
| Tissue specificity | Expressed in several hair follicle cell types: basal and peripheral matrix cells, and cells of the outer and inner root sheaths. Expressed in colon. Present in cortical neurons (at protein level). Expressed in breast cancer tissues (at protein level) (PubMed:29367600).Highest expression level in adrenal tissue. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol. |
| Background | CTNNB1,also known as β-Catenin,is an evolutionarily conserved,multifunctional intracellular protein. CTNNB1 was originally identified in cell adherens junctions (Ajs) where it functions to bridge the cytoplasmic domain of cadherins to a-catenin and the actin cytoskeleton. Besides its essential role in the Ajs,CTNNB1 is also a key downstream component of the canonical Wnt pathway that plays diverse and critical roles in embryonic development and adult tissue homeostasis. Deregulation of CTNNB1 activity is associated with multiple diseases including cancers. . |
Images
Western Blot analysis of various samples using Catenin beta Polyclonal Antibody at dilution of 1:1000.
Immunohistochemistry analysis of paraffin-embedded Human colon tissue using Catenin beta Polyclonal Antibody at dilution of 1:300.
Immunohistochemistry analysis of paraffin-embedded Mosue kidney using Catenin beta Polyclonal Antibody at dilution of 1:500.
Immunofluorescence analysis of Mouse stomach using Catenin beta Polyclonal Antibody at dilution of 1:300.
Immunohistochemistry analysis of paraffin-embedded Human Colon using Catenin beta Polyclonal Antibody(Elabscience® Product Detected by Lifespan).
客户发表文献
- 文献: Overexpression of AGR2vH, an oncogenic AGR2 spliced transcript, potentiates tumorigenicity and proteomic alterations in cholangiocarcinoma cell
样品类型: KKU-213A cell,KKU-213L5 cell
