Cathepsin B Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-10208
宿主: Rabbit
反应性: H,M,R
应用: IHC
Overview
| Synonyms | Amyloid precursor protein secretase,APP secretase,APPS,CATB,Cathepsin B heavy chain,Cathepsin B1,CathepsinB,CPSB,CTSB,cysteine protease,OTTHUMP00000116009,OTTHUMP00000229510,OTTHUMP00000229511,OTTHUMP00000229512,OTTHUMP00000229514,OTTHUMP00000229515,OTTHUMP00000229516,Preprocathepsin B,CTSB抗体 |
| Swissprot | P07858 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Recombinant protein of human CTSB |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:150-1:500 |
| Concentration | 0.8 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Lysosome. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | The protein encoded by this gene is a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer disease, the most common cause of dementia. Overexpression of the encoded protein, which is a member of the peptidase C1 family, has been associated with esophageal adenocarcinoma and other tumors. At least five transcript variants encoding the same protein have been found for this gene. |
