CBFA2T2 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-19075
宿主: Rabbit
反应性: H,M
应用: WB
Overview
| Synonyms | AML1 MTG8,cbfa2t2,Core binding factor runt domain alpha subunit 2 translocated to 2,core-binding factor, runt domain, alpha subunit 2,DKFZp313F2116,EHT,ETO homolog on chromosome 20,ETO homologous on chromosome 20,MTG 8 like protein,MTG 8 related protein 1,MTG8 like protein,MTG8 related protein 1,MTG8-like protein,MTG8-related protein 1,MTG8R,MTGR 1,Myeloid translocation gene related protein 1,Myeloid translocation related protein 1,Myeloid translocation-related protein 1,p85,Protein CBFA2T2,ZMYND 3,ZMYND3,CBFA2T2抗体 |
| Swissprot | O43439 |
| Source | Rabbit |
| Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human CBFA2T2 |
| Application | WB(Detection kit: E-IR-R304) |
| Recommended dilution | WB,,1:1000-1:5000; |
| Concentration | 1.26mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Nucleus. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described. |
