CBX5 Monoclonal Antibody
| 规格： | / 20μL / 60μL / 120μL |
| 价格： | / ￥580 / ￥1420 / ￥2310 |
货号：E-AB-22146
宿主: Mouse
反应性: H,M,R
应用: WB,IHC-p
Overview
| Synonyms | Antigen p25,CBX5,CBX5,CG8409,Chromobox 5,Chromobox homolog 5 (HP1 alpha homolog,Drosophila),Chromobox homolog 5,Chromobox protein homolog 5,Epididymis luminal protein 25,HEL25,Heterochromatin protein 1 alpha,Heterochromatin protein 1,Heterochromatin protein 1 homolog alpha,HP1 alpha,HP1 alpha homolog,HP1,HP1A,HP1Hs alpha,Su(var)205,HP-1α Mouse (5E3)抗体 |
| Swissprot | P45973 |
| Source | Mouse |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Recombinant Protein of HP-1α |
| Application | WB(Detection kit: E-IR-R304),IHC-p(Detection kit: E-IR-R213) |
| Recommended dilution | WB,,1:500-2000;IHC,,1:50-300; |
| Concentration | 1mg/mL |
| Clonality | Monoclonal |
Properties
| Cellular localization | Nucleus. Chromosome. Chromosome>centromere. Component of centromeric and pericentromeric heterochromatin. Associates with chromosomes during mitosis. Associates specifically with chromatin during metaphase and anaphase. |
| Clone No | Clone:7B6 |
|---|---|
| Isotype | IgG |
| Purification | Protein A purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide, 50% glycerol, pH7.4 |
| Background | This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified. |
Images
Western Blot analysis of 1) Hela, 2)3T3, 3) PC-12 cells using CBX5 Monoclonal Antibody at dilution of 1:1000.
Immunohistochemistry of paraffin-embedded Human uterus tissue using CBX5 Monoclonal Antibody at dilution of 1:200.
Immunofluorescence analysis of Human uterus tissue using CBX5 Monoclonal Antibody at dilution of 1:200.
