CCL18/PARC Polyclonal Antibody(Capture/Detector)
| 规格： | / 25μg / 100μg |
| 价格： | / 询价 / 询价 |
货号：AN004630P
货期：咨询
宿主: Rabbit
反应性: H
应用: ELISA Capture/Detector
Overview
| Synonyms | CKb;TSC;DCCK;DC-CK;Eotaxin;AMAC-1;CCL26;CKb7;DC-CK1;Eotaxin-3;IMAC;MIP-4;MIP-4a;SCYA26;TSC-1;AMAC1;MIP4;PARC;SCYA18;CCL18;AMAC-1;CKb7;DCCK1;DC-CK1;MIP-4;Alternative macrophage activation associated CC chemokine 1;Alternative macrophage activation-associated CC chemokine 1;CC chemokine PARC;C-C Motif Chemokine 18;CCL18(4-69);Dendritic cell chemokine 1;Macrophage inflammatory protein 4;Pulmonary and activation regulated chemokine;Pulmonary and activation-regulated chemokine;Small inducible cytokine A18;Small-inducible cytokine A18 |
| Swissprot | P55774 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Recombinant Human CCL18/PARC Protein expressed by E.coli |
| Application | ELISA Capture/Detector |
| Recommended dilution | ELISA Capture,,2-8 μg/mL;ELISA Detector,,0.1-0.4 μg/mL |
| Concentration | 1mg/mL |
| Clonality | Polyclonal |
Properties
| Isotype | IgG |
| Purification | Antigen Affinity Purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions. |
| Storage buffer | Sterile PBS ,pH 7.4 |
| Background | CCL18, also known as alternative macrophage activation-associated CC chemokine (AMAC)-1, macrophage inflammatory protein (MIP)-4, and dendritic cell chemokine (DC-CK1), is a novel CC chemokine that is highly homologous to MIP-1 alpha (61% amino acid (aa) sequence identity). CCL18 cDNA encodes an 89 aa residue precursor protein with a 20 aa putative signal peptide that is cleaved to generate a 69 aa residue mature protein which lacks potential glycosylation sites. In vitro, CCL18 mRNA expression is induced in alternatively activated macrophages by Th2 cytokines such as IL-4, IL-10, and IL-13, and inhibited by IFN‑ gamma. CCL18 mRNA is also expressed by GM-CSF/IL-4-induced monocyte-derived dendritic cells. In vivo, CCL18 is highly expressed in lung and placenta but is not expressed in epidermal Langerhans cells. Recombinant CCL18 has been shown to chemoattract naive T cells but not monocytes or neutrophils. |
