CD274 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-19627
宿主: Rabbit
反应性: H
应用: WB,IHC
Overview
| Synonyms | B7 H,B7 H1,B7 homolog 1,B7-H1,B7H,B7H1,CD 274,CD274,CD274 antigen,CD274 molecule,MGC142294,MGC142296,OTTHUMP00000021029,PD L1,PD-L1,PD1L1,PDCD1 ligand 1,PDCD1L1,PDCD1LG1,PDL 1,PDL1,Programmed cell death 1 ligand 1,Programmed death ligand 1,RGD1566211,CD274抗体 |
| Swissprot | Q9NZQ7 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Synthetic peptide of human CD274 |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213) |
| Recommended dilution | WB,,1:500-1:2000;IHC,,1:50-1:100; |
| Concentration | 0.72mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cell membrane and Endomembrane system. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | Programmed cell death ligand 1(CD274,or B7-H1,PD-L1),is the first member of B7 family to be discovered. B7 family molecules are type I transmembrane proteins belonging to the immunoglobulin superfamily. In concert with their CD28 family receptors,the B7s are key regulators of the adaptive immune response. CD274 is suggested a negative regulator of T and B cell,and play important role in mediating tolerance of lymphocytes to self-antigens. It also involved in the costimulatory signal,essential for T-cell proliferation and production of IL10 and IFNG,in an IL2-dependent and a PDCD1-independent manner. PD-L1 is a 290 aa transmembrane protein with a calculated molecular weight of 33 kDa,the apparent molecular weight has been reported as 45-70 kDa,suggesting probable glycosylation . |
