CD2AP Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-16309
宿主: Rabbit
反应性: H
应用: WB,IHC
Overview
| Synonyms | Adapter protein CMS,AL024079,C78928,Cas ligand with multiple SH3 domains,CD2 associated protein,CD2-associated protein,CD2AP,CD2AP,CMS,Mesenchyme to epithelium transition protein with SH3 domains 1,METS 1,Mets1,CD2AP抗体 |
| Swissprot | Q9Y5K6 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Synthetic peptide of human CD2AP |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213) |
| Recommended dilution | WB,,1:1000-1:5000;IHC,,1:100-1:300; |
| Concentration | 0.2mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm>cytoskeleton. Cell projection>ruffle. Colocalizes with F-actin and BCAR1/p130Cas in membrane ruffles. Located at podocyte slit diaphragm between podocyte foot processes (By similarity). During late anaphase and telophase, concentrates in the vicinity of the midzone microtubules and in the midbody in late telophase. |
| Tissue specificity | Widely expressed in fetal and adult tissues. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | This gene encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites, SH3 domains, and a proline-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes to membrane ruffles, lipid rafts, and the leading edges of cells. It is implicated in dynamic actin remodeling and membrane trafficking that occurs during receptor endocytosis and cytokinesis. Haploinsufficiency of this gene is implicated in susceptibility to glomerular disease. |
Images
Western Blot analysis of A431 and Raji cell using CD2AP Polyclonal Antibody at dilution of 1:1000
Immunohistochemistry of paraffin-embedded Human Lymphoma using CD2AP Polyclonal Antibody at dilution of 1:70
Immunohistochemistry of paraffin-embedded Human liver cancer using CD2AP Polyclonal Antibody at dilution of 1:70
