CDK4 Polyclonal Antibody
| 规格： | / 60μL / 120μL / 200μL |
| 价格： | / ￥1380 / ￥2220 / ￥3300 |
货号：E-AB-70100
宿主: Rabbit
反应性: H,R
应用: IHC
Overview
| Synonyms | Cdk 4,cdk4,CDK4 protein,CDK4,Cell division kinase 4,Cell division protein kinase 4,CMM 3,CMM3,Crk3,Cyclin dependent kinase 4,Cyclin-dependent kinase 4,Melanoma cutaneous malignant 3,MGC14458,p34 cdk4,PSK J3,PSK-J3,CDK4抗体 |
| Swissprot | P11802,P30285,P35426 |
| Source | Rabbit |
| Reactivity | Human,Rat |
| Immunogen | KLH conjugated Synthetic peptide corresponding to Mouse CDK4 |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:100 |
| Concentration | 210 μg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm, Membrane, Nucleus |
| Tissue specificity | Highest expression level in right ovary |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol. |
| Background | The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. |
Images
Immunohistochemistry analysis of paraffin-embedded human stomach cancer using CDK4 Polyclonal Antibody at dilution of 1:100.
Immunohistochemistry analysis of paraffin-embedded human breast using CDK4 Polyclonal Antibody at dilution of 1:100.
Immunohistochemistry analysis of paraffin-embedded human colon using CDK4 Polyclonal Antibody at dilution of 1:100.
Immunohistochemistry analysis of paraffin-embedded rat ovary using CDK4 Polyclonal Antibody at dilution of 1:100.
Immunohistochemistry analysis of paraffin-embedded rat testis using CDK4 Polyclonal Antibody at dilution of 1:100.
