CENPC Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-14864
宿主: Rabbit
反应性: H
应用: IHC
Overview
| Synonyms | CENP-C 1,CENP-C,CENPC,CENPC1,Centromere autoantigen C,Centromere autoantigen C1,Centromere protein C 1,Centromere protein C,hcp-4,ICEN7,Interphase centromere complex protein 7,MIF2,CENPC抗体 |
| Swissprot | Q03188 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Recombinant protein of human CENPC |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:50-1:200 |
| Concentration | 0.6 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Nucleus. Chromosome>centromere>kinetochore. Localizes exclusively in the kinetochore domain of centromeres. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | Centromere protein C 1 is a centromere autoantigen and a component of the inner kinetochore plate. The protein is required for maintaining proper kinetochore size and a timely transition to anaphase. A putative pseudogene exists on chromosome 12. Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. |
