CEP55 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-11074
宿主: Rabbit
反应性: H,R
应用: WB
Overview
| Synonyms | C10orf3,cancer/testis antigen 111,Centrosomal protein 55kDa,Centrosomal protein of 55 kDa,CEP 55,Cep55,CEP55,CT111,FLJ10540,Up regulated in colon cancer 6,Up-regulated in colon cancer 6,URCC 6,URCC6,CEP55抗体 |
| Swissprot | Q53EZ4 |
| Source | Rabbit |
| Reactivity | Human,Rat |
| Immunogen | Recombinant protein of human CEP55 |
| Application | WB(Detection kit: E-IR-R304) |
| Recommended dilution | WB,,1:200-1:1000; |
| Concentration | 0.7 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm>cytoskeleton>centrosome>centriole. Cytoplasm>cytoskeleton>centrosome. Cleavage furrow. Midbody. Present at the centrosomes at interphase. A small portion is associated preferentially with the mother centriole, whereas the majority localizes to the pericentriolar material. During mitosis, loss of affinity for the centrosome at the onset of prophase and diffusion throughout the cell. This dissociation from the centrosome is phosphorylation-dependent. May remain localized at the centrosome during mitosis in certain cell types. Appears at the cleavage furrow in late anaphase and in the midbody in cytokinesis. |
| Tissue specificity | Widely expressed, mostly in proliferative tissues. Highly expressed in testis. Intermediate levels in adult and fetal thymus, as well as in various cancer cell lines. Low levels in different parts of the digestive tract, bone marrow, lymph nodes, placenta, fetal heart and fetal spleen. Hardly detected in brain. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | Centrosomal protein of 55 kDa is a protein that in humans is encoded by the CEP55 gene.CEP55 is a mitotic phosphoprotein that plays a key role in cytokinesis, the final stage of cell division.Interacts (phosphorylated on Ser-425 and Ser-428) with PLK1.Interacts with AKAP9; the interaction occurs in interphase and is lost upon mitotic entry.Interacts with PCNT; the interaction occurs in interphase and is lost upon mitotic entry.Interacts with PDCD6IP; the interaction is direct; CEP55 binds PDCD6IP in a 2:1 stoechiometry; PDCD6IP competes with TSG101 for the same binding site. |
