CK-17 Monoclonal Antibody
| 规格： | / 20μL / 60μL / 120μL |
| 价格： | / ￥580 / ￥1420 / ￥2310 |
货号：E-AB-22039
宿主: Mouse
反应性: H
应用: WB,IHC-p,IF,IP
Overview
| Synonyms | 39.1,CK 17,CK-17,Cytokeratin-17,K17,K1C17,Keratin 17,keratin 17 epitope S1,keratin 17 epitope S2,keratin 17 epitope S4,Keratin 17,type I,Keratin,Keratin type I cytoskeletal 17,keratin,type i cytoskeletal 17 [version 1],Keratin-17,KRT17,PC,PC2,PCHC1,type I cytoskeletal 17,CK17抗体 |
| Swissprot | Q04695 |
| Source | Mouse |
| Reactivity | Human |
| Immunogen | Synthetic Peptide |
| Application | WB(Detection kit: E-IR-R304),IHC-p(Detection kit: E-IR-R213),IF,IP |
| Recommended dilution | WB 1:500-1:2000, IHC 1:50-300, IF 1:50-1:200, IP 1:100-1:300 |
| Concentration | 1mg/mL |
| Clonality | Monoclonal |
Properties
| Cellular localization | Cytoplasm |
| Tissue specificity | Expressed in the outer root sheath and medulla region of hair follicle specifically from eyebrow and beard, digital pulp, nail matrix and nail bed epithelium, mucosal stratified squamous epithelia and in basal cells of oral epithelium, palmoplantar epidermis and sweat and mammary glands. Also expressed in myoepithelium of prostate, basal layer of urinary bladder, cambial cells of sebaceous gland and in exocervix (at protein level). |
| Clone No | Clone:2K5 |
|---|---|
| Isotype | IgG |
| Purification | Protein A purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide, 50% glycerol, pH7.4 |
| Background | May play a role in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair. |
Images
Western Blot analysis of 1) Hela, 2) MCF7, 3) 293T cells using CK-17 Monoclonal Antibody at dilution of 1:2000.
Immunohistochemistry of paraffin-embedded Human liver tissue using CK-17 Monoclonal Antibody at dilution of 1:200.
Immunofluorescence analysis of Human breast tissue using CK-17 Monoclonal Antibody at dilution of 1:200.
