CK-6A/B/C Monoclonal Antibody
| 规格： | / 20μL / 60μL / 120μL |
| 价格： | / ￥580 / ￥1420 / ￥2310 |
货号：E-AB-22038
宿主: Mouse
反应性: H
应用: WB,IHC-p,IF
Overview
| Synonyms | CK-6A,CK-6D,CK6A,CK6C,CK6D,Cytokeratin-6A,Cytokeratin-6D,K2C6A,K6A,K6C,K6D,keratin 6A,Keratin,Keratin,type II cytoskeletal 6A,Keratin-6A,Krt6a,KRT6C,KRT6D,type II cytoskeletal 6A,Type-II keratin Kb6,Cytokeratin 6抗体 |
| Swissprot | P02538,P04259,P48668 |
| Source | Mouse |
| Reactivity | Human |
| Immunogen | Synthetic Peptide |
| Application | WB(Detection kit: E-IR-R304),IHC-p(Detection kit: E-IR-R213),IF |
| Recommended dilution | WB 1:500-1:2000, IHC 1:50-300, IF 1:100-1:300 |
| Concentration | 1mg/mL |
| Clonality | Monoclonal |
Properties
| Cellular localization | Cytoskeleton,keratin filament,Cytosol,Extracellular region or secreted,extracellular exosome,Nucleus,Other locations:membrane |
| Clone No | Clone:3B6 |
|---|---|
| Isotype | IgG |
| Purification | Protein A purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide, 50% glycerol, pH7.4 |
| Background | The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. This KRT6 gene in particular encodes the most abundant isoform. Mutations in these genes have been associated with pachyonychia congenita. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. |
Images
Western Blot analysis of 1) Hela, 2) HepG2 cells using CK-6A/B/C Monoclonal Antibody at dilution of 1:2000.
Immunohistochemistry of paraffin-embedded Human breast cancer tissue using CK-6A/B/C Monoclonal Antibody at dilution of 1:200.
Immunofluorescence analysis of Human breast cancer tissue using CK-6A/B/C Monoclonal Antibody at dilution of 1:200.
