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CKAP2 Polyclonal Antibody

规格: / 20μL / 60μL / 120μL / 200μL
价格: / ¥420 / ¥1010 / ¥1640 / ¥2365

货号:E-AB-11085

宿主: Rabbit

反应性: H

应用: IHC

  • 详情
  • Overview

    Synonyms AI461656,AW228814,CKAP 2,Ckap2,CKAP2,CTCL tumor antigen se20 10,CTCL tumor antigen se20-10,Cytoskeleton associated protein 2,Cytoskeleton-associated protein 2,DKFZp686L1238,FLJ10749,LB1,se20 10,TMAP,Tumor and microtubule associated protein,Tumor associated microtubule associated protein,Tumor- and microtubule-associated protein,CKAP2抗体
    Swissprot Q8WWK9
    Source Rabbit
    Reactivity Human
    Immunogen Recombinant protein of human CKAP2
    Application IHC(Detection kit: E-IR-R213)
    Recommended dilution IHC,,1:50-1:200
    Concentration 0.5 mg/mL
    Clonality Polyclonal

    Properties

    Cellular localization Cytoplasm>cytoskeleton. Cytoplasm>cytoskeleton. Cytoplasm>cytoskeleton>spindle. Cytoplasm>cytoskeleton>spindle pole. Contrary to the ectopically expressed protein, endogenous CKAP2 does not colocalize with microtubules in G1, S and early G2. At late G2 and prophase after separation of duplicated centrosomes, colocalizes with gamma-tubulin and centrosome-proximal microtubules. From prometaphase through anaphase B, colocalizes with mitotic spindle poles and spindle microtubules. During cytokinesis, absent from midbody microtubules.
    Tissue specificity Abundant in testis, thymus, and in tumor derived cell lines, while barely detectable in liver, prostate, and kidney.
    Isotype IgG
    Purification Affinity purification
    Conjugation Unconjugated
    Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
    Storage buffer PBS with 0.05% sodium azide, 50% glycerol, PH7.3
    Background This gene encodes a cytoskeleton-associated protein that stabalizes microtubules and plays a role in the regulation of cell division. The encoded protein is itself regulated through phosphorylation at multiple serine and threonine residues. There is a pseudogene of this gene on chromosome 14. Alternative splicing results in multiple transcript variations.
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