CKAP2 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-11085
宿主: Rabbit
反应性: H
应用: IHC
Overview
| Synonyms | AI461656,AW228814,CKAP 2,Ckap2,CKAP2,CTCL tumor antigen se20 10,CTCL tumor antigen se20-10,Cytoskeleton associated protein 2,Cytoskeleton-associated protein 2,DKFZp686L1238,FLJ10749,LB1,se20 10,TMAP,Tumor and microtubule associated protein,Tumor associated microtubule associated protein,Tumor- and microtubule-associated protein,CKAP2抗体 |
| Swissprot | Q8WWK9 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Recombinant protein of human CKAP2 |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:50-1:200 |
| Concentration | 0.5 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm>cytoskeleton. Cytoplasm>cytoskeleton. Cytoplasm>cytoskeleton>spindle. Cytoplasm>cytoskeleton>spindle pole. Contrary to the ectopically expressed protein, endogenous CKAP2 does not colocalize with microtubules in G1, S and early G2. At late G2 and prophase after separation of duplicated centrosomes, colocalizes with gamma-tubulin and centrosome-proximal microtubules. From prometaphase through anaphase B, colocalizes with mitotic spindle poles and spindle microtubules. During cytokinesis, absent from midbody microtubules. |
| Tissue specificity | Abundant in testis, thymus, and in tumor derived cell lines, while barely detectable in liver, prostate, and kidney. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | This gene encodes a cytoskeleton-associated protein that stabalizes microtubules and plays a role in the regulation of cell division. The encoded protein is itself regulated through phosphorylation at multiple serine and threonine residues. There is a pseudogene of this gene on chromosome 14. Alternative splicing results in multiple transcript variations. |
