Claudin 1 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-15674
宿主: Rabbit
反应性: H,M,R
应用: WB,IHC
Overview
| Synonyms | Claudin-1,Claudin1,CLD 1,CLD1,CLD1,CLDN 1,Cldn1,ILVASC,SEMP 1,SEMP1,Senescence associated epithelial membrane protein 1,Senescence associated epithelial membrane protein,Senescence-associated epithelial membrane protein,CLDN1抗体 |
| Swissprot | O95832 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Synthetic peptide of human CLDN1 |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213) |
| Recommended dilution | WB,,1:2000-1:5000;IHC,,1:100-1:300; |
| Concentration | 1 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cell junction, tight junction. Cell membrane. |
| Tissue specificity | Strongly expressed in liver and kidney. Expressed in heart, brain, spleen, lung and testis. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome. |
Images
Western Blot analysis of Hela cell using Claudin 1 Polyclonal Antibody at dilution of 1:1900
Immunohistochemistry of paraffin-embedded Human liver cancer using Claudin 1 Polyclonal Antibody at dilution of 1:150
Immunohistochemistry of paraffin-embedded Human ovarian cancer using Claudin 1 Polyclonal Antibody at dilution of 1:150
