Claudin 7 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-15677
宿主: Rabbit
反应性: H,M,R
应用: WB,IHC
Overview
| Synonyms | CEPTR L2,CEPTRL 2,CEPTRL2,Claudin 1,Claudin 9,Claudin-7,Claudin1,Claudin7,Claudin9,CLD7,CLDN 7,CLDN-7,CLDN7,Clostridium perfringens enterotoxin receptor like 2,CPETR L2,CPETRL 2,CPETRL2,Hs.84359,CLDN7抗体 |
| Swissprot | O95471 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Synthetic peptide of human CLDN7 |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213) |
| Recommended dilution | WB,,1:1000-1:3000;IHC,,1:50-1:150; |
| Concentration | 0.3 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cell membrane. Lateral cell membrane. Cell junction>tight junction. Co-localizes with EPCAM at the lateral cell membrane and tight junction. |
| Tissue specificity | Expressed in kidney, lung and prostate. Isoform 1 seems to be predominant, except in some normal prostate samples, where isoform 2 is the major form. Down-regulated in breast cancers, including ductal carcinoma in situ (DCIS), lobular carcinoma in situ (LCIS) and invasive ductal carcinoma (IDC) (at protein level), as well as in several cancer cell lines. Loss of expression correlates with histological grade, occurring predominantly in high-grade lesions. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc.. Alternatively spliced transcript variants encoding different isoforms have been found. |
Images
Western Blot analysis of Human liver cancer tissue using Claudin 7 Polyclonal Antibody at dilution of 1:1050
Immunohistochemistry of paraffin-embedded Human colon cancer using Claudin 7 Polyclonal Antibody at dilution of 1:50
Immunohistochemistry of paraffin-embedded Human stomach cancer using Claudin 7 Polyclonal Antibody at dilution of 1:50
