COL18A1 Polyclonal Antibody
规格: | / 60μL / 120μL / 200μL |
价格: | / ¥1380 / ¥2220 / ¥3300 |
货号:E-AB-70197
宿主: Rabbit
反应性: H,M
应用: IHC
Overview
Synonyms | Antiangiogenic agent,COIA1,Col18a1,Collagen alpha 1(XVIII) chain,Collagen type XVIII alpha 1,Endostatin,KNO,KNO1,KS,Multi functional protein MFP,COL18A1抗体 |
Swissprot | P39060,P39061 |
Source | Rabbit |
Reactivity | Human,Mouse |
Immunogen | KLH conjugated Synthetic peptide corresponding to Mouse Endostatin |
Application | IHC(Detection kit: E-IR-R213) |
Recommended dilution | IHC,,1:300-1:1000 |
Concentration | 1.1 mg/mL |
Clonality | Polyclonal |
Properties
Cellular localization | Secreted, extracellular space, extracellular matrix. |
Tissue specificity | Present in multiple organs with Highest levels in liver, lung and kidney.Highest expression level in left coronary artery. |
Isotype | IgG |
Purification | Affinity purification |
Conjugation | Unconjugated |
Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
Storage buffer | PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol. |
Background | This gene encodes the alpha chain of type XVIII collagen.This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains.The proteolytically produced C-terminal fragment of type XVIII collagen is endostatin, a potent antiangiogenic protein.Mutations in this gene are associated with Knobloch syndrome.The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure.Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
Images
Immunohistochemistry analysis of paraffin-embedded human kidney using COL18A1 Polyclonal Antibody at dilution of 1:400.
Immunohistochemistry analysis of paraffin-embedded mouse liver using COL18A1 Polyclonal Antibody at dilution of 1:400.
Immunohistochemistry analysis of paraffin-embedded mouse kidney using COL18A1 Polyclonal Antibody at dilution of 1:400.