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COL18A1 Polyclonal Antibody

规格: / 60μL / 120μL / 200μL
价格: / ¥1380 / ¥2220 / ¥3300

货号:E-AB-70197

宿主: Rabbit

反应性: H,M

应用: IHC

  • 详情
  • Overview

    Synonyms Antiangiogenic agent,COIA1,Col18a1,Collagen alpha 1(XVIII) chain,Collagen type XVIII alpha 1,Endostatin,KNO,KNO1,KS,Multi functional protein MFP,COL18A1抗体
    Swissprot P39060,P39061
    Source Rabbit
    Reactivity Human,Mouse
    Immunogen KLH conjugated Synthetic peptide corresponding to Mouse Endostatin
    Application IHC(Detection kit: E-IR-R213)
    Recommended dilution IHC,,1:300-1:1000
    Concentration 1.1 mg/mL
    Clonality Polyclonal

    Properties

    Cellular localization Secreted, extracellular space, extracellular matrix.
    Tissue specificity Present in multiple organs with Highest levels in liver, lung and kidney.Highest expression level in left coronary artery.
    Isotype IgG
    Purification Affinity purification
    Conjugation Unconjugated
    Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
    Storage buffer PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol.
    Background This gene encodes the alpha chain of type XVIII collagen.This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains.The proteolytically produced C-terminal fragment of type XVIII collagen is endostatin, a potent antiangiogenic protein.Mutations in this gene are associated with Knobloch syndrome.The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure.Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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